Smile House® today announced the official opening of its Tribeca flagship location at 55 Warren Street, unveiling a first-of-its-kind integrative dental practice where the mouth is recognized as the gateway to overall health and longevity. Founded by globally renowned aesthetic and functional dentistry expert Dr. Jonathan B. Levine, Smile House introduces a new category of hospitality-inspired care, uniting restorative dentistry, aesthetics and advanced diagnostic technology. With an in-house laboratory and a curated team of collaborating specialists, the result is unparalleled patient care.
Smile House is not a traditional dental practice. Its dentistry reimagined, where advanced diagnostics meet longevity in a setting designed to nurture both body and mind. Located within a restored two-story landmark building in Tribeca, the flagship welcomes patients into a calming, light-filled environment crafted to soothe the senses and support healing. Every detail from guided breathwork, weighted blankets, microbiome-friendly refreshments and a 500-square-foot outdoor space reflects an intentional approach to care. At its heart, a striking curated bookcase serves as both an educational and inspirational hub, featuring works on longevity and health, alongside imagery from Dr. Levine and his family’s philanthropic dental work, reflecting the practice’s deep commitment to global wellness and giving back. Care at Smile House is guided by Smile Housepitality™, a philosophy that merges clinical excellence, genuine human connection, and five-star service. Every element, from the personalized treatments to the thoughtful amenities, is designed to turn each visit into a restorative ritual, redefining the healthcare setting.
“The traditional dental model is fragmented and outdated,” says Dr. Jonathan B. Levine, Founder of Smile House. “Patients are often shuffled from office to office, seeing specialists who treat isolated symptoms rather than the whole person. For decades, my work has been dedicated to showing that oral health is not just about the beauty of a smile, it is central to the health of the entire body. At Smile House, we’ve built this philosophy into every detail with one guiding principle: oral health is the foundation of longevity.”
At the heart of the Smile House experience is Mouth Mapping®, a proprietary diagnostic that functions like a full-body MRI for your mouth. Using 3D imaging, AI-enhanced scans, and salivary testing it creates a 360° map across aesthetics, structure, function and biology, helping patients understand how oral health connects to their overall wellness. With nearly half of adults over 30 experiencing periodontal disease, a silent driver of inflammation linked to heart disease, diabetes and accelerated aging, this approach empowers patients to take an active role in their health with an integrative and preventative approach.
Smile House operates as a multi-specialty ecosystem, ensuring each plan is comprehensive and personalized. By uniting these disciplines under one roof, Smile House eliminates fragmentation and creates continuity of care, with each patient’s experience and treatment plan being overseen by a curated team of experts collaborating across multiple disciplines including:
- Preventive, restorative, cosmetic and prosthodontic dentistry
- Periodontics, orthodontics and oral surgery
- Pediatric dental care
- World class ceramists and dental laboratory technicians
- Airway-centered sleep medicine and TMJ therapy
- Laser, biologic and microbiome-supportive treatments
- Advanced whitening with GLO Science™ technology
- EMFACE technology for facial aesthetics and jaw tension relief
The vision for Smile House was born from the work of the GLO Good Foundation, cofounded in 2011 by Dr. Levine with his wife Stacey, together with their two sons, Cody and Julian, in partnership with longtime friend and patient, Lenny Kravitz, they launched their mission in Eleuthera, Bahamas, bringing free comprehensive dental and medical care to underserved communities. There, the team witnessed first-hand the power of collaboration between medicine and dentistry, working side-by-side to transform lives through total health. That experience became the blueprint for Smile House – a space where the connection between mouth, body, and overall wellbeing is at the heart of care. The practice continues to honor the foundation’s mission through ongoing philanthropic initiatives extending the same world-class standard of care to those who need it most.
Smile House is the dental practice redefining care through dental longevity. Rooted in the belief that oral health is total body health, Smile House is a first-of-its-kind destination for integrative dentistry and wellness. Led by Dr. Jonathan B. Levine, DMD, a world-renowned dentist and trusted expert behind some of the most photographed smiles in the world, the practice delivers hyper-personalized, longevity-focused care built on four pillars of dental longevity: Aesthetics, Structure, Function and Biology, offering experiences and results that go far beyond traditional dentistry. Smile House’s proprietary Mouth Mapping® uses advanced diagnostics (3D imaging, AI-driven scans, and salivary testing) to illuminate life-changing insights and detect potential risks early as the foundation of personalized care. From there, a multi-specialty team curated by Dr. Levine delivers all-encompassing functional and aesthetic outcomes with Smile Housepitality™, an elevated, patient-first experience grounded in calm, quality and world-class care. Smile House represents not just a new destination, but the beginning of a movement where dentistry becomes a foundation for lifelong wellness.
About Dr. Jonathan B. Levine
Dr. Jonathan B. Levine, DMD, is a world-renowned professor, inventor, philanthropist, and expert in aesthetic and functional dentistry with over 35 years of pioneering work that integrates advanced science, innovative technology and systemic wellness to transform not just smiles, but lives. As the founder of Smile House and JBL New York City, he holds 29 patents, including the groundbreaking GLO Science teeth-whitening system, and has earned the trust of high-profile patients, including some of the most photographed smiles in the world. An accomplished educator, author and media contributor, Dr. Levine frequently shares his expertise on platforms such as The Today Show, CNN and The New York Times. Through his GLO Good Foundation, he works to break down barriers in global oral health, delivering essential care and education to underserved communities worldwide. At the heart of Dr. Levine’s approach is servant leadership with a deep commitment to elevating others, fostering growth, and inspiring leadership in those around him. He builds collaborative, high-performing teams that reflect his dedication to mentorship, teamwork, and advancing the dental profession.
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