August 5, 2025

#300: Leo Grady, PhD, Founder and CEO of Jona

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Today, I’m joined by Leo Grady, PhD, founder and CEO of Jona.

Jona uses metagenomic sequencing and machine learning to deliver personalized metabolic health insights, predicting how factors like diet and lifestyle affect the gut.

In this episode, we discuss upgrading microbiome testing with AI technology.

We also cover:

  • Why gut tests could outpace blood tests
  • Building AI to read medical literature at scale
  • Using digital twins to predict health outcomes

The Fitt Insider Podcast is brought to you by EGYM. Visit EGYM.com to learn more about its smart workout solutions for fitness and health facilities.


Chapters:
(00:00) Introduction
(00:20) Leo’s Background
(02:15) Why the Microbiome is the Perfect AI Application
(06:10) Building AI to Read Medical Literature at Scale
(09:55) From Testing to Interventions
(13:30) Avoiding Supplement Sales for Credibility
(15:25) Direct Consumer and Clinical Partnerships
(17:25) Digital Twin Technology in Healthcare
(21:15) Three Customer Types and Testing Frequency
(23:00) Microbiome vs Blood Testing
(27:25) Education and Category Building Challenges
(29:25) Technology Applications Beyond Microbiome
(32:10) Health Tracking Integrations
(37:00) Regulatory Considerations and Future Diagnostics
(37:45) 2025 Roadmap and New Features
(39:15) Conclusion

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