Stride Launches At-Home MTHFR & Methylation DNA Test in the US and UK

Stride, the at-home health testing and supplements company founded by Olympic medalist Andrew Steele, has launched its MTHFR & Methylation Test in the US and UK. The test reads both common variants of the MTHFR gene, C677T and A1298C, alongside COMT and 16 more genes across the five methylation cycles.

MTHFR has become one of the most searched genes in consumer health. Many people first hear about it on podcasts or social media, often framed around the word “mutation”, and look for a test without knowing what a single result can tell them. Stride built the test around the view that one gene rarely tells the whole story. It reads MTHFR in the context of the wider methylation system, including MTR and MTRR, which affect how the body recycles vitamin B12, and COMT and MAOA, which are involved in breaking down neurotransmitters.

How it works

The test uses a cheek swab taken at home. In the US, kits ship by FedEx with a prepaid return label to the lab. Results arrive in about 10 business days in MyStride, Stride’s online platform, as five methylation reports, one for each cycle. Results are presented as tendencies rather than diagnoses.

MyStride then generates an AI-powered protocol that ranks what to focus on first, from food choices to B vitamin forms. Each customer also has a 1:1 video consultation with a Stride nutrition and dietetics expert to review the results and the plan. Because genes don’t change, the test only needs to be taken once, and customers can later upgrade to Stride’s Optimal Health DNA Test, which covers 110 genes across nutrition, fitness, sleep, stress and skin health, without giving a new sample.

Why DNA rather than blood

MTHFR variants are part of a person’s DNA. They are the same in every cell and do not change over a lifetime, so they can be read from a painless cheek swab instead of a blood draw. Many methylation blood tests measure something different: levels of homocysteine, folate or B12 at a single point in time, which shift with diet and supplements. Stride positions the two as complementary: genes show how a person’s methylation tends to work, while blood markers show where they are today.

Product range

The MTHFR & Methylation Test sits alongside Stride’s existing range: the Optimal Health DNA Test, the Gut Health Test and, in the UK, the Optimal Bloods Test and the StrideOne membership. Stride also makes its own supplements, including MS-01, a methylated B vitamin complex with methylfolate, methylcobalamin (B12), B6 and TMG. The MTHFR & Methylation Test has a list price of $329 in the US and £165 in the UK, and will be $197.40 and £99 during Stride’s Black Friday sale from November 20 to 30.

“People come to us having heard about MTHFR, often worried by what they’ve read,” said Andrew Steele, founder and CEO of Stride. “One gene never tells the whole story, so we read it alongside the rest of the methylation cycles and turn the results into a plan people can actually follow, with an expert to talk it through.”

The test is not a diagnostic test. Stride advises anyone who is pregnant, breastfeeding or taking medication to speak to their doctor before making changes to supplements.