August 21, 2025 - News

Building the Metabolic Health OS

CGMs meet GLP-1s.
Man wearing a CGM while pouring a smoothie
Signos

Modern crises, modern solutions.

Tech talk. As obesity and diabetes surge, lifestyle interventions are being prescribed alongside GLP-1s — with CGMs and predictive tech emerging as behavior change tools.

FDA x CGM. Signos gained FDA clearance for its Dexcom-powered weight loss program, logging glucose response to food, sleep, stress, and exercise. Coaching members to ~8% of body weight in six months, the platform now links to nonprescription CGM Stelo and is pushing for insurance coverage.

Double down. Twin Health just raised $53M at a $950M valuation for its digital twin model, integrating smartwatch, CGM, and device data to coach lifestyle change.

Publishing results, 71% of members reversed diabetes, while 81% eliminated GLP-1 use.

In the mix. Mainstreaming metabolic health, Levels synced with Dexcom’s Stelo last week but remains classified as wellness, not medical-grade. Meanwhile, nutrition-focused Virta Health now prescribes GLP-1s but also promises to curb their usage.

Punchline: With or without GLP-1s, the companies building metabolic health’s operating systems could control the on-ramp to lasting health.

Ryan Deer
Ryan Deer
Strategic intelligence for the future of health.

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